![]() Smith successfully displayed the recombinant peptide at the N-terminal of pIII capsid protein of M13 filamentous bacteriophage, and his discovery laid the foundation for drug discovery based on phage display. Nevertheless, finding inhibitors of these protein targets, especially inhibitors of unknown functional proteins, presents a challenge. Based on computer analysis, an increasing number of new potential antibacterial targets with unknown or known functions, such as flavin mononucleotide riboswitches and the lysine riboswitch, have been reported. ![]() The rapid development of genome sequencing technology provides a huge space for the discovery of antibiotics based on new targets. ![]() Currently, existing clinical antibiotics cannot fully meet the needs of clinical infection control however, the development of antibiotics lags behind because the discovery of traditional antibiotics depends on the structural modification of natural products synthesized by bacteria, which requires a long time and high investment in addition, obtaining new antibiotics with novel structure and action mechanism is difficult. The continuous emergence of multidrug-resistant (MDR) and super-bacteria has brought challenges to antibacterial treatment worldwide.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |